Geometry, epistasis, and developmental patterning
نویسندگان
چکیده
منابع مشابه
Geometry, epistasis, and developmental patterning.
Developmental signaling networks are composed of dozens of components whose interactions are very difficult to quantify in an embryo. Geometric reasoning enumerates a discrete hierarchy of phenotypic models with a few composite variables whose parameters may be defined by in vivo data. Vulval development in the nematode Caenorhabditis elegans is a classic model for the integration of two signal...
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Approaches to gene interactions based on sign epistasis have been highly influential in recent time. Sign epistasis is useful for relating local and global properties of fitness landscapes, as well as for analyzing evolutionary trajectories and constraints. The geometric theory of gene interactions, on the other hand, provides complete information on interactions in terms of minimal dependence ...
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Calcium ions generate ubiquitous cellular signals. Calcium signals play an important role in development. The most obvious example is fertilization, where calcium signals and calcium waves are triggered by the sperm and are responsible for activating the egg from dormancy and cell cycle arrest. Calcium signals also appear to contribute to cell cycle progression during the rapid cell cycles of e...
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Note: This is a book chapter that will have embedded in it a Box explaining the geometry of phenotype landscapes. The text for the Box, which includes Figures 1 and 2, is at the end of the manuscript.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1201505109